Compound Detail
CHEMBL70149
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Basic Information
| ChEMBL ID | CHEMBL70149 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NQVBNOPSVRCGSI-CMDGGOBGSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
291.4
MW (Da)
4.42
ALogP
3
HBA
0
HBD
31.4
PSA (Ų)
0.71
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor CHEMBL2095189 | IC50 | 8.3 | 8.3 | 5.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor | IC50 | = | 5.0 | nM | 8.3 | Inhibition of human PDGF receptor phosphorylation; 0.001-0.005 | 8035419 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8035419 | 10.1021/jm00040a003 | Platelet-derived growth factor receptor | 1 |
| 8035419 | 10.1021/jm00040a003 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine