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Compound Detail

CHEMBL72932

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COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cccc(F)c67)CC5)CC4)OCCO3)cc2)cc1

Basic Information

ChEMBL ID CHEMBL72932
Phase Preclinical
Structure Type MOL
InChI Key SVZWHYBKLRIBMQ-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

658.8
MW (Da)
6.04
ALogP
7
HBA
0
HBD
85.4
PSA (Ų)
0.24
QED
2
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C37H39FN2O6S
MW 658.79
Aromatic Rings 4
Heavy Atoms 47
NP-Likeness -0.76

Activity Summary

Ki 1 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 9.0 9.0 1.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11527721 10.1016/s0960-894x(01)00435-8 Muscarinic acetylcholine receptor M2 1
11527721 10.1016/s0960-894x(01)00435-8 Muscarinic acetylcholine receptors; M1 & M2 1
11527721 10.1016/s0960-894x(01)00435-8 Muscarinic acetylcholine receptors; M2 & M3 1
11527721 10.1016/s0960-894x(01)00435-8 ADMET 1

Data from ChEMBL 36 via Core Engine