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Compound Detail

CHEMBL73741

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CCCCCc1nsnc1C1=CCCN(C)C1.O=C(O)C(=O)O

Basic Information

ChEMBL ID CHEMBL73741
Phase Preclinical
Structure Type MOL
InChI Key XEFJKAOGCNMJOQ-UHFFFAOYSA-N
Parent Compound CHEMBL1179396
Active Moiety CHEMBL1179396
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

251.4
MW (Da)
2.99
ALogP
4
HBA
0
HBD
29.0
PSA (Ų)
0.75
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H23N3O4S
MW 341.43
Aromatic Rings 1
Heavy Atoms 17
NP-Likeness -0.31

Activity Summary

IC50 2 meas. best 6.84

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL276
IC50 6.84 6.805 146.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1613751 10.1021/jm00090a019 Muscarinic acetylcholine receptor M1 2
1613751 10.1021/jm00090a019 Cavia porcellus 2
1613751 10.1021/jm00090a019 Oryctolagus cuniculus 1

Data from ChEMBL 36 via Core Engine