Compound Detail
CHEMBL76148
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Basic Information
| ChEMBL ID | CHEMBL76148 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FRZBZMLGMSIYIV-INIZCTEOSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
332.5
MW (Da)
2.53
ALogP
3
HBA
0
HBD
40.6
PSA (Ų)
0.83
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prolyl endopeptidase CHEMBL2460 | IC50 | 7.17 | 6.72 | 67.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prolyl endopeptidase | IC50 | = | 67.0 | nM | 7.17 | Inhibitory activity was evaluated against Post-proline cleaving enzyme from bovi... | 8691432 |
| Prolyl endopeptidase | IC50 | = | 540.0 | nM | 6.27 | Inhibitory activity was evaluated against Post-proline cleaving enzyme from bovi... | 8691432 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8691432 | 10.1021/jm950858c | Prolyl endopeptidase | 2 |
Data from ChEMBL 36 via Core Engine