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Compound Detail

CHEMBL77622

DOPEXAMINE
🧪 Phase II
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🧪 Phase II
Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL77622
Name DOPEXAMINE
Phase Phase II
Structure Type MOL
InChI Key RYBJORHCUPVNMB-UHFFFAOYSA-N
Therapeutic ✓ Yes

Known Names

Dopexamina Dopexamine FPL 60278 FPL-60278
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
20
Publications
4
Known Names
2
Indications

Molecular Properties

356.5
MW (Da)
3.62
ALogP
4
HBA
4
HBD
64.5
PSA (Ų)
0.33
QED
0
Ro5 Violations
13
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Natural Product
USAN Year 1985

Extended Properties

Molecular Formula C22H32N2O2
MW 356.51
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness 0.23

Indications

Cardiovascular Diseases Shock, Septic

ATC Classification

C01CA14
dopexamine
Level 1: CARDIOVASCULAR SYSTEM
Level 2: CARDIAC THERAPY

Literature References

PubMed DOI Target Context # Activities
37468498 10.1038/s41467-023-40064-9 Nuclear receptor subfamily 1 group I member 2 3
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M2 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2B 2
37468498 10.1038/s41467-023-40064-9 Androgen receptor 2
37468498 10.1038/s41467-023-40064-9 Progesterone receptor 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 1A 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 Gamma-aminobutyric acid receptor subunit alpha-1 2
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2A 2
37468498 10.1038/s41467-023-40064-9 Cannabinoid receptor 1 2
37468498 10.1038/s41467-023-40064-9 Kappa-type opioid receptor 1
37468498 10.1038/s41467-023-40064-9 Alpha-2B adrenergic receptor 1
37468498 10.1038/s41467-023-40064-9 Adenosine receptor A3 1
37468498 10.1038/s41467-023-40064-9 Adenosine receptor A1 1
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2C 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent dopamine transporter 1
37468498 10.1038/s41467-023-40064-9 Beta-1 adrenergic receptor 1
37468498 10.1038/s41467-023-40064-9 Glutamate receptor ionotropic, NMDA 1 1
37468498 10.1038/s41467-023-40064-9 Voltage-gated inwardly rectifying potassium channel KCNH2 1

Data from ChEMBL 36 via Core Engine