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Compound Detail

CHEMBL802

MINOXIDIL
💊 Approved Drug
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💊 Approved Drug
Nc1cc(N2CCCCC2)nc(N)[n+]1[O-]
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL802
Name MINOXIDIL
Phase Approved
Structure Type MOL
InChI Key ZFMITUMMTDLWHR-UHFFFAOYSA-N
Therapeutic ✓ Yes
Active Moiety CHEMBL906

Known Names

Alopexil Alostil Loniten Lonolox Men's rogaine Minodyl Minoxidil Minoxidil (for men) Minoxidil (for women) Minoxidil extra strength (for men) Minoximen Mintop +16 more
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
20
Publications
28
Known Names
6
Indications
1
Mechanisms

Molecular Properties

209.2
MW (Da)
-0.13
ALogP
5
HBA
2
HBD
95.1
PSA (Ų)
0.50
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1979
Availability OTC
Chirality Achiral

Routes of Administration

Oral Topical

Flags

Black Box Warning Natural Product Prodrug
USAN Stem -dil
USAN Year 1970

Extended Properties

Molecular Formula C9H15N5O
MW 209.25
Aromatic Rings 1
Heavy Atoms 15
NP-Likeness -1.22

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Sulfonylurea receptor 2, Kir6.2 opener OPENER Sulfonylurea receptor 2, Kir6.2 ✓ ✓

Indications

Alopecia Alopecia Alopecia Hypertension Ovarian Neoplasms Acne Vulgaris

ATC Classification

C02DC01
minoxidil
Level 1: CARDIOVASCULAR SYSTEM
Level 2: ANTIHYPERTENSIVES
D11AX01
minoxidil
Level 1: DERMATOLOGICALS
Level 2: OTHER DERMATOLOGICAL PREPARATIONS

Drug Warnings

Black Box Warning
cardiotoxicity
Country: United States

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL3885881 Rattus norvegicus 332
16472241 10.2174/1570163043334794 Hepatotoxicity 18
22194678 10.1371/journal.pcbi.1002310 Hepatotoxicity 14
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
3361578 10.1021/jm00400a003 Rattus norvegicus 10
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
18391949 10.1038/nchembio.79 SK-N-MC 4
34547896 10.1021/acs.jmedchem.1c00823 Transthyretin 4
26832215 10.1016/j.bmcl.2016.01.048 NON-PROTEIN TARGET 3
20014752 10.1021/tx900326k Hepatotoxicity 3
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2A 3
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 3
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
37468498 10.1038/s41467-023-40064-9 Beta-2 adrenergic receptor 2
22931300 10.1021/tx300075j Cytochrome P450 3A4 2
18834112 10.1021/jm800656v Amine oxidase [flavin-containing] A 2
37468498 10.1038/s41467-023-40064-9 Gamma-aminobutyric acid receptor subunit alpha-1 2
26948801 10.1016/j.drudis.2016.02.015 Homo sapiens 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2

Data from ChEMBL 36 via Core Engine