Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL82440

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
O=C(O)Cc1c[nH]c2ccc(Br)cc12

Basic Information

ChEMBL ID CHEMBL82440
Phase Preclinical
Structure Type MOL
InChI Key WTFGHMZUJMRWBK-UHFFFAOYSA-N
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names

Molecular Properties

254.1
MW (Da)
2.56
ALogP
1
HBA
2
HBD
53.1
PSA (Ų)
0.86
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C10H8BrNO2
MW 254.08
Aromatic Rings 2
Heavy Atoms 14
NP-Likeness -0.30

Activity Summary

IC50 3 meas. best 4.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 4.22 4.22 60000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 60000.0 nM 4.22 Inhibition of PDF2 17201406

Literature References

PubMed DOI Target Context # Activities
12182852 10.1016/s0960-894x(02)00505-x Molecular identity unknown 1
12182852 10.1016/s0960-894x(02)00505-x V79 1
17201406 10.1021/jm060910c Peptide deformylase, mitochondrial 1
17201406 10.1021/jm060910c Bacillus subtilis 1
17201406 10.1021/jm060910c Peptide deformylase 1A, chloroplastic/mitochondrial 1
17201406 10.1021/jm060910c Peptide deformylase 1
17201406 10.1021/jm060910c Escherichia coli 1
17201406 10.1021/jm060910c Unchecked 1
17481907 10.1016/j.bmc.2007.04.005 No relevant target 1
17481907 10.1016/j.bmc.2007.04.005 Albumin 1
24467709 10.1021/jm401432c Unchecked 1

Data from ChEMBL 36 via Core Engine