Compound Detail
CHEMBL82833
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Basic Information
| ChEMBL ID | CHEMBL82833 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BHUVUNZKZDLBRF-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
3
Publications
0
Known Names
Molecular Properties
296.8
MW (Da)
2.89
ALogP
4
HBA
2
HBD
64.3
PSA (Ų)
0.65
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 CHEMBL1875 | EC50 | 6.9 | 6.9 | 125.9 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Fu | 0.34 | - | Sepia officinalis |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | EC50 | = | 125.89 | nM | 6.9 | Agonist activity against 5-HT4 receptor in rat esophageal muscularis mucosae | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(01)80413-3 | 5-hydroxytryptamine receptor 4 | 2 |
| 30398862 | 10.1021/acs.jmedchem.8b01281 | Unchecked | 1 |
| 30398862 | 10.1021/acs.jmedchem.8b01281 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine