Compound Detail
CHEMBL85529
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Basic Information
| ChEMBL ID | CHEMBL85529 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RLDKSMWNRZTDIS-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
471.1
MW (Da)
4.31
ALogP
5
HBA
0
HBD
39.7
PSA (Ų)
0.67
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 5.68 | 5.68 | 2100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 2100.0 | nM | 5.68 | In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]far... | 9873573 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9873573 | 10.1016/s0960-894x(98)00439-9 | Protein farnesyltransferase | 1 |
Data from ChEMBL 36 via Core Engine