Compound Detail
CHEMBL8678
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Basic Information
| ChEMBL ID | CHEMBL8678 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WOGIVBNRXNCUHE-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
274.2
MW (Da)
1.19
ALogP
7
HBA
2
HBD
130.9
PSA (Ų)
0.53
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 4.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | Ki | 4.58 | 4.58 | 26000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | Ki | = | 26000.0 | nM | 4.58 | Displacement of [3H]AMPA from Ionotropic glutamate receptor AMPA in rat cortical... | 11855983 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11855983 | 10.1021/jm010995b | Glutamate receptor ionotropic, NMDA 1 | 1 |
| 11855983 | 10.1021/jm010995b | Glutamate receptor ionotropic, AMPA | 1 |
| 11855983 | 10.1021/jm010995b | Glutamate receptor ionotropic, kainate | 1 |
Data from ChEMBL 36 via Core Engine