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Compound Detail

CHEMBL880

FAMCICLOVIR
💊 Approved Drug
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💊 Approved Drug
CC(=O)OCC(CCn1cnc2cnc(N)nc21)COC(C)=O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL880
Name FAMCICLOVIR
Phase Approved
Structure Type MOL
InChI Key GGXKWVWZWMLJEH-UHFFFAOYSA-N
Therapeutic ✓ Yes
Active Moiety CHEMBL4594375

Known Names

BRL-42810 Famciclovir Famvir NSC-758921
0
Targets
3
Activities
1
Assay Types
15
PK Parameters
20
Publications
4
Known Names
9
Indications
1
Mechanisms

Molecular Properties

321.3
MW (Da)
0.54
ALogP
9
HBA
1
HBD
122.2
PSA (Ų)
0.73
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1994
Availability Prescription
Chirality Achiral

Routes of Administration

Oral

Flags

Natural Product Prodrug
USAN Stem -vir
USAN Year 1992

Extended Properties

Molecular Formula C14H19N5O4
MW 321.34
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness -0.20

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Human herpesvirus 1 DNA polymerase inhibitor INHIBITOR DNA polymerase catalytic subunit ✓ ✓

Indications

Autoimmune Diseases Eye Infections Herpes Genitalis Herpes Labialis Herpes Zoster Virus Diseases Herpes Simplex Meniere Disease Multiple Sclerosis

ATC Classification

J05AB09
famciclovir
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIVIRALS FOR SYSTEMIC USE
S01AD07
famciclovir
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS

Activity Summary

IC50 3 meas.

Pharmacokinetic Data

Parameter Value Units Species
AUC 3160.0 ng.hr.mL-1 Homo sapiens
AUC 2110.0 ng.hr.mL-1 Homo sapiens
AUC 8770.0 ng.hr.mL-1 Homo sapiens
AUC 8940.0 ng.hr.mL-1 Homo sapiens
AUC 8540.0 ng.hr.mL-1 Homo sapiens
Cmax 2302.86 nM Homo sapiens
Cmax 2147.26 nM Homo sapiens
Cmax 10082.78 nM Homo sapiens
Cmax 10736.29 nM Homo sapiens
F 77.0 % Homo sapiens
T1/2 1.89 hr Homo sapiens
Tmax 1.02 hr Homo sapiens
Tmax 4.0 hr Homo sapiens
Tmax 1.0 hr Homo sapiens
Tmax 0.75 hr Homo sapiens

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL3885881 Rattus norvegicus 434
31158845 10.1038/s41586-019-1291-3 ADMET 104
- 10.5281/zenodo.13943903 ADMET 88
16472241 10.2174/1570163043334794 Hepatotoxicity 18
22194678 10.1371/journal.pcbi.1002310 Hepatotoxicity 14
20160046 10.1128/aac.01508-09 Homo sapiens 13
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
31158845 10.1038/s41586-019-1291-3 SGNH hydrolase-type esterase domain-containing protein 7
2754699 10.1021/jm00128a012 Mus musculus 6
19273678 10.1128/aac.01054-08 Homo sapiens 6
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 4
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2B 3
31158845 10.1038/s41586-019-1291-3 Acetyl esterase (Acetylxylosidase) 3
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M2 3
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2A 3
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 1A 3
20014752 10.1021/tx900326k Hepatotoxicity 3
31158845 10.1038/s41586-019-1291-3 Acylhydrolase 3
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 3

Data from ChEMBL 36 via Core Engine