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Compound Detail

CHEMBL89131

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O=C(O)COc1ccc(C(=O)CNC(=O)C2CCNCC2)cc1OCC(=O)O

Basic Information

ChEMBL ID CHEMBL89131
Phase Preclinical
Structure Type MOL
InChI Key YHELUMJILNUDBU-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

394.4
MW (Da)
-0.09
ALogP
7
HBA
4
HBD
151.3
PSA (Ų)
0.40
QED
0
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H22N2O8
MW 394.38
Aromatic Rings 1
Heavy Atoms 28
NP-Likeness -0.67

Activity Summary

IC50 1 meas. best 5.01

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Homo sapiens
CHEMBL372
IC50 5.01 5.01 9800.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Homo sapiens IC50 = 9800.0 nM 5.01 Inhibitory activity against ADP-mediated human platelet aggregation in human pla... -

Literature References

PubMed DOI Target Context # Activities
- 10.1016/0960-894X(96)00476-3 Homo sapiens 1
- 10.1016/0960-894X(96)00476-3 Integrin alpha-IIb/beta-3 1

Data from ChEMBL 36 via Core Engine