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Compound Detail

CHEMBL9020

N-PHENYL-PHTHALIMIDE
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O=C1c2ccccc2C(=O)N1c1ccccc1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL9020
Name N-PHENYL-PHTHALIMIDE
Phase Preclinical
Structure Type MOL
InChI Key MFUPLJQNEXUUDW-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
20
Publications
0
Known Names

Molecular Properties

223.2
MW (Da)
2.49
ALogP
2
HBA
0
HBD
37.4
PSA (Ų)
0.70
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C14H9NO2
MW 223.23
Aromatic Rings 2
Heavy Atoms 17
NP-Likeness -0.97

Activity Summary

IC50 1 meas. best 4.09

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vero
CHEMBL391
 IC50 4.09 4.09 82000.0 1

Pharmacokinetic Data

Parameter Value Units Species
Ka - - -

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Vero IC50 = 82000.0 nM 4.09 Cytotoxicity against Vero cells 17234303

Literature References

PubMed DOI Target Context # Activities
- 10.1007/s00044-013-0870-3 Mus musculus 16
26355531 10.1016/j.ejmech.2015.08.058 Lipoprotein lipase 4
6131131 10.1021/jm00356a022 Mus musculus 3
16183272 10.1016/j.bmcl.2005.08.086 HUVEC 3
15603947 10.1016/j.bmcl.2004.10.072 HL-60 3
17378546 10.1021/jm061471k Unchecked 2
9288167 10.1021/jm970109q HL-60 2
10843222 10.1016/s0960-894x(00)00161-x Unchecked 2
9288167 10.1021/jm970109q WI-38 1
- 10.1016/S0960-894X(00)80236-X Polyunsaturated fatty acid 5-lipoxygenase 1
10843222 10.1016/s0960-894x(00)00161-x Lysosomal acid glucosylceramidase 1
17378546 10.1021/jm061471k Liver carboxylesterase 1 1
17234303 10.1016/j.ejmech.2006.12.003 Vero 1
19583260 10.1021/jm900461w Fatty-acid amide hydrolase 1 1
19583260 10.1021/jm900461w Monoglyceride lipase 1
21778064 10.1016/j.bmc.2011.06.070 Amine oxidase [flavin-containing] A 1
21778064 10.1016/j.bmc.2011.06.070 Amine oxidase [flavin-containing] B 1
- 10.1007/s00044-011-9603-7 NUGC 1
- 10.1007/s00044-011-9603-7 HL-60 1
11909713 10.1016/s0960-894x(02)00084-7 Prostaglandin G/H synthase 2 1

Data from ChEMBL 36 via Core Engine