Compound Detail
CHEMBL92118
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Basic Information
| ChEMBL ID | CHEMBL92118 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FPQARIIBDDMZEU-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
405.5
MW (Da)
4.31
ALogP
4
HBA
3
HBD
100.6
PSA (Ų)
0.58
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 5.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 5 CHEMBL3227 | Ki | 5.47 | 5.47 | 3400.0 | 1 |
| Metabotropic glutamate receptor 1 CHEMBL3772 | Ki | 5.24 | 5.24 | 5700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 5 | Ki | = | 3400.0 | nM | 5.47 | Agonist potency against cloned metabotropic glutamate receptor 5 | 10893301 |
| Metabotropic glutamate receptor 1 | Ki | = | 5700.0 | nM | 5.24 | Agonist potency against cloned human metabotropic glutamate receptor 1 | 10893301 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 1 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 5 | 1 |
Data from ChEMBL 36 via Core Engine