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Compound Detail

CHEMBL93746

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CC(C)(C)c1ccc(C(=O)O)cc1

Basic Information

ChEMBL ID CHEMBL93746
Phase Preclinical
Structure Type MOL
InChI Key KDVYCTOWXSLNNI-UHFFFAOYSA-N
0
Targets
5
Activities
1
Assay Types
0
PK Parameters
14
Publications
0
Known Names

Molecular Properties

178.2
MW (Da)
2.68
ALogP
1
HBA
1
HBD
37.3
PSA (Ų)
0.72
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C11H14O2
MW 178.23
Aromatic Rings 1
Heavy Atoms 13
NP-Likeness -0.61

Activity Summary

IC50 5 meas.

Literature References

PubMed DOI Target Context # Activities
2909740 10.1021/jm00121a047 Rattus norvegicus 6
17258462 10.1016/j.bmc.2006.12.038 Unchecked 2
24269123 10.1016/j.bmcl.2013.11.004 NAD-dependent protein deacetylase sirtuin-1 2
8667357 10.1021/jm950589q ADMET 1
1527790 10.1021/jm00096a014 No relevant target 1
1527790 10.1021/jm00096a014 ADMET 1
8411009 10.1021/jm00072a012 Unchecked 1
3950915 10.1021/jm00153a009 Thiopurine S-methyltransferase 1
24269123 10.1016/j.bmcl.2013.11.004 NAD-dependent protein deacetylase sirtuin-2 1
24269123 10.1016/j.bmcl.2013.11.004 Unchecked 1
915902 10.1021/jm00221a013 Unchecked 1
32031798 10.1021/acs.jmedchem.9b01746 ATP-dependent Clp protease proteolytic subunit 1
34591488 10.1021/acs.jmedchem.1c01215 No relevant target 1
36690437 10.1021/acs.jmedchem.2c01723 Unchecked 1

Data from ChEMBL 36 via Core Engine