Compound Detail
CHEMBL96153
TERIKALANT 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL96153 |
| Name | TERIKALANT |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | UIZPEXQHMIZQPQ-IBGZPJMESA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
2
Known Names
Molecular Properties
381.5
MW (Da)
4.84
ALogP
4
HBA
0
HBD
30.9
PSA (Ų)
0.72
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
IC50 4 meas. best 7.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 7.52 | 6.83 | 30.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 30.0 | nM | 7.52 | Inhibitory concentration against IKr potassium channel | 15324906 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 251.19 | nM | 6.6 | Inhibition of human Potassium channel HERG expressed in mammalian cells | 12873512 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 251.19 | nM | 6.6 | Inhibitory concentration against potassium channel HERG | 15911273 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 251.19 | nM | 6.6 | Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniq... | 18448342 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12873512 | 10.1016/s0960-894x(03)00492-x | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 15324906 | 10.1016/j.bmcl.2004.06.070 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 15911273 | 10.1016/j.bmcl.2005.03.080 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 18448342 | 10.1016/j.bmc.2008.04.028 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
Data from ChEMBL 36 via Core Engine