Compound Detail
CHEMBL985
UREA 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL985 |
| Name | UREA |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | XSQUKJJJFZCRTK-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
20
Publications
24
Known Names
16
Indications
Molecular Properties
60.1
MW (Da)
-0.98
ALogP
1
HBA
2
HBD
69.1
PSA (Ų)
0.37
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1982 |
| Availability | Prescription |
| Chirality | Achiral |
Indications
Cicatrix Dermatitis, Atopic Diabetes Mellitus Diabetes Mellitus, Type 2 Radiodermatitis Carcinoma, Hepatocellular Hand-Foot Syndrome Head and Neck Neoplasms Non-alcoholic Fatty Liver Disease Pain Psoriasis Skin Diseases Argininosuccinic Aciduria Carbamoyl-Phosphate Synthase I Deficiency Disease Citrullinemia Ornithine Carbamoyltransferase Deficiency Disease
ATC Classification
B05BC02
carbamide
Level 1: BLOOD AND BLOOD FORMING ORGANS
Level 2: BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
D02AE01
carbamide
Level 1: DERMATOLOGICALS
Level 2: EMOLLIENTS AND PROTECTIVES
D02AE51
carbamide, combinations
Level 1: DERMATOLOGICALS
Level 2: EMOLLIENTS AND PROTECTIVES
Activity Summary
EC50 1 meas. best 7.64
Ki 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Olfactory receptor 51E2 CHEMBL4523454 | EC50 | 7.64 | 7.64 | 23.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Olfactory receptor 51E2 | EC50 | = | 23.0 | nM | 7.64 | Agonist activity at PSGR/OR51E2 (unknown origin) expressed in human Hana3A cells... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1007/s00044-012-0086-y | Rattus norvegicus | 16 |
| 31447248 | 10.1016/j.bmc.2019.115052 | Complement C5 | 3 |
| 20014752 | 10.1021/tx900326k | Hepatotoxicity | 3 |
| 9836611 | 10.1021/jm9810102 | No relevant target | 2 |
| - | 10.1039/C5MD00275C | Pseudomonas aeruginosa | 2 |
| - | 10.1039/C5MD00275C | Staphylococcus aureus | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 20373811 | 10.1021/jm901846t | No relevant target | 2 |
| 10841786 | 10.1021/jm991156g | Liposome | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 17827020 | 10.1016/j.bmc.2007.07.050 | Skin | 1 |
| 19734051 | 10.1016/j.bmc.2009.08.022 | Caco-2 | 1 |
| 20373811 | 10.1021/jm901846t | ADMET | 1 |
| 15715475 | 10.1021/jm049549p | No relevant target | 1 |
| 20373811 | 10.1021/jm901846t | Brain | 1 |
| 10841786 | 10.1021/jm991156g | Homo sapiens | 1 |
| 3882967 | 10.1021/jm00381a013 | No relevant target | 1 |
| 7392035 | 10.1021/jm00180a022 | Rattus norvegicus | 1 |
| 8691461 | 10.1021/jm960068i | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine