DNA gyrase subunit B · SINGLE PROTEIN · Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
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As of 2026-09-14Protein identity stays anchored to UniProt P0A4L9. Use UniProt P0A4L9 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P0A4L9 as the stable identity anchor, then attach disease evidence before program review.
DNA gyrase subunit B
Review this target as DNA gyrase subunit B, mapped to UniProt P0A4L9. Sequence length is 648 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats DNA gyrase subunit B as ChEMBL target CHEMBL1075021, mapped to UniProt P0A4L9. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | DNA gyrase subunit B |
| Target Type | SINGLE PROTEIN |
| Organism | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) |
| UniProt | P0A4L9 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | DNA gyrase subunit B |
| UniProt Accession | P0A4L9 |
| Component Type | Protein |
| Sequence Length | 648 aa |
DNA gyrase subunit B
Review this target as DNA gyrase subunit B, mapped to UniProt P0A4L9. Sequence length is 648 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL578362 | 7.44 | IC50 | 36.0 | Preclinical |
| CHEMBL36506 | 7.43 | IC50 | 37.0 | Approved |
| CHEMBL568020 | 7.36 | IC50 | 44.0 | Preclinical |
| CHEMBL565765 | 7.32 | IC50 | 48.0 | Preclinical |
| CHEMBL565750 | 7.29 | IC50 | 51.0 | Preclinical |
| CHEMBL577478 | 7.28 | IC50 | 53.0 | Preclinical |
| CHEMBL584265 | 7.28 | IC50 | 52.0 | Preclinical |
| CHEMBL583049 | 7.25 | IC50 | 56.0 | Preclinical |
| CHEMBL578361 | 7.12 | IC50 | 75.0 | Preclinical |
| CHEMBL577053 | 7.04 | IC50 | 92.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 35 | 6.8 |