ParE · SINGLE PROTEIN · Streptococcus pneumoniae
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As of 2026-09-14Protein identity stays anchored to UniProt Q7X1P7. Use UniProt Q7X1P7 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q7X1P7 as the stable identity anchor, then attach disease evidence before program review.
DNA topoisomerase (ATP-hydrolyzing)
Review this target as ParE, mapped to UniProt Q7X1P7. ChEMBL maps the protein component as DNA topoisomerase (ATP-hydrolyzing). Sequence length is 638 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats ParE as ChEMBL target CHEMBL1075022, mapped to UniProt Q7X1P7. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | ParE |
| Target Type | SINGLE PROTEIN |
| Organism | Streptococcus pneumoniae |
| UniProt | Q7X1P7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | DNA topoisomerase (ATP-hydrolyzing) |
| UniProt Accession | Q7X1P7 |
| Component Type | Protein |
| Sequence Length | 638 aa |
DNA topoisomerase (ATP-hydrolyzing)
Review this target as ParE, mapped to UniProt Q7X1P7. ChEMBL maps the protein component as DNA topoisomerase (ATP-hydrolyzing). Sequence length is 638 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL568020 | 6.92 | IC50 | 119.0 | Preclinical |
| CHEMBL565776 | 6.83 | IC50 | 147.0 | Preclinical |
| CHEMBL577478 | 6.6 | IC50 | 250.0 | Preclinical |
| CHEMBL578362 | 6.59 | IC50 | 258.0 | Preclinical |
| CHEMBL578120 | 6.58 | IC50 | 265.0 | Preclinical |
| CHEMBL578361 | 6.55 | IC50 | 280.0 | Preclinical |
| CHEMBL567804 | 6.44 | IC50 | 366.0 | Preclinical |
| CHEMBL583049 | 6.44 | IC50 | 364.0 | Preclinical |
| CHEMBL565572 | 6.43 | IC50 | 367.0 | Preclinical |
| CHEMBL568021 | 6.43 | IC50 | 373.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 35 | 6.1 |