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Target Snapshot

CHEMBL1075023 Target Snapshot

5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase · SINGLE PROTEIN · Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

3Compounds
1Assays
0Approved Drugs
3.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt A0A0H2UPP7. Use UniProt A0A0H2UPP7 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt A0A0H2UPP7 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Protein anchor
adenosylhomocysteine nucleosidase

adenosylhomocysteine nucleosidase

Review this target as 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, mapped to UniProt A0A0H2UPP7. ChEMBL maps the protein component as adenosylhomocysteine nucleosidase. Sequence length is 230 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt A0A0H2UPP7 Protein 230 aa
Open protein block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase as ChEMBL target CHEMBL1075023, mapped to UniProt A0A0H2UPP7. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
SINGLE PROTEIN · Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
As of 2026-09-14
ChEMBL target ID
CHEMBL1075023
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
A0A0H2UPP7
adenosylhomocysteine nucleosidase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Labeladenosylhomocysteine nucleosidase
UniProt AccessionA0A0H2UPP7
Component TypeProtein
Sequence Length230 aa

adenosylhomocysteine nucleosidase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, mapped to UniProt A0A0H2UPP7. ChEMBL maps the protein component as adenosylhomocysteine nucleosidase. Sequence length is 230 aa.

Mapped IDA0A0H2UPP7
Review name5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
OrganismStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Assay Mix

Activity Type Distribution

KI3.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL405346 7.62 Ki 24.0 Preclinical
CHEMBL405371 7.08 Ki 84.0 Preclinical
CHEMBL407216 6.82 Ki 150.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
1
6.5
1
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
3
Tested Compounds
1
Assay Types
Binding — 1 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 3 7.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine