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Target Snapshot

CHEMBL1075028 Target Snapshot

Alpha carbonic anhydrase · SINGLE PROTEIN · Stylophora pistillata

55Compounds
2Assays
12Approved Drugs
93.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt B5SU02. Use UniProt B5SU02 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt B5SU02 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Alpha carbonic anhydrase as ChEMBL target CHEMBL1075028, mapped to UniProt B5SU02. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Alpha carbonic anhydrase
SINGLE PROTEIN · Stylophora pistillata
As of 2026-09-14
ChEMBL target ID
CHEMBL1075028
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
B5SU02
Carbonic anhydrase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Alpha carbonic anhydrase is the right protein anchor across sources, using UniProt B5SU02 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCarbonic anhydrase
UniProt AccessionB5SU02
Component TypeProtein
Sequence Length323 aa

Carbonic anhydrase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Alpha carbonic anhydrase, mapped to UniProt B5SU02. ChEMBL maps the protein component as Carbonic anhydrase. Sequence length is 323 aa.

Mapped IDB5SU02
Review nameAlpha carbonic anhydrase
OrganismStylophora pistillata
Clinical Profile

Clinical Phase Distribution

12
Approved
5
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

KI93.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL355001 11.0 Ki 0.01 Preclinical
CHEMBL21485 9.17 Ki 0.68 Preclinical
CHEMBL364571 9.11 Ki 0.78 Preclinical
CHEMBL68253 9.09 Ki 0.81 Preclinical
CHEMBL20 7.8 Ki 16.0 Approved
CHEMBL218490 7.74 Ki 18.1 Approved
CHEMBL7146 7.71 Ki 19.7 Preclinical
CHEMBL73962 7.69 Ki 20.4 Preclinical
CHEMBL19 7.67 Ki 21.2 Approved
CHEMBL6633 7.59 Ki 25.4 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
2
5.5
18
6.0
12
6.5
22
7.0
20
7.5
0
8.0
0
8.5
3
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VALDECOXIB
CHEMBL865
Approved 2001
ZONISAMIDE
CHEMBL750
Approved 2000
CELECOXIB
CHEMBL118
Approved 1998
BRINZOLAMIDE
CHEMBL220491
Approved 1998
TOPIRAMATE
CHEMBL220492
Approved 1996
DORZOLAMIDE
CHEMBL218490
Approved 1994
SULFANILAMIDE
CHEMBL21
Approved 1985
ETHOXZOLAMIDE
CHEMBL18
Approved 1982
MAFENIDE
CHEMBL419
Approved 1969
METHAZOLAMIDE
CHEMBL19
Approved 1959
DICHLORPHENAMIDE
CHEMBL17
Approved 1958
ACETAZOLAMIDE
CHEMBL20
Approved 1953
Assay Landscape

Assay Landscape

2
Total Assays
92
Tested Compounds
1
Assay Types
Binding — 2 assays, 92 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 37 7.0
single protein format 1 55 7.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine