Dihydrofolate reductase · SINGLE PROTEIN · Bos taurus
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As of 2026-09-13Protein identity stays anchored to UniProt P00376. Use UniProt P00376 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P00376 as the stable identity anchor, then attach disease evidence before program review.
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt P00376. Sequence length is 187 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydrofolate reductase as ChEMBL target CHEMBL1075051, mapped to UniProt P00376. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Dihydrofolate reductase is the right protein anchor across sources, using UniProt P00376 as the stable mapping.
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| Preferred Name | Dihydrofolate reductase |
| Target Type | SINGLE PROTEIN |
| Organism | Bos taurus |
| UniProt | P00376 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydrofolate reductase |
| UniProt Accession | P00376 |
| Component Type | Protein |
| Sequence Length | 187 aa |
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt P00376. Sequence length is 187 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL34259 | 8.77 | IC50 | 1.7 | Approved |
| CHEMBL1800937 | 8.64 | IC50 | 2.3 | Preclinical |
| CHEMBL3115740 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL155016 | 8.27 | IC50 | 5.4 | Preclinical |
| CHEMBL154152 | 8.27 | IC50 | 5.4 | Preclinical |
| CHEMBL1801203 | 8.25 | IC50 | 5.6 | Preclinical |
| CHEMBL1801200 | 8.21 | IC50 | 6.1 | Preclinical |
| CHEMBL1800946 | 8.16 | IC50 | 6.9 | Preclinical |
| CHEMBL1800939 | 8.14 | IC50 | 7.2 | Preclinical |
| CHEMBL1800944 | 8.12 | IC50 | 7.6 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 60 | 182 | 6.2 |
| single protein format | 26 | 63 | 5.4 |
| tissue-based format | 1 | 5 | 6.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | — |