Glycine receptor subunit alpha-3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O75311. Use UniProt O75311 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O75311 as the stable identity anchor, then attach disease evidence before program review.
Glycine receptor subunit alpha-3
Review this target as Glycine receptor subunit alpha-3, mapped to UniProt O75311. Sequence length is 464 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Glycine receptor subunit alpha-3 as ChEMBL target CHEMBL1075092, mapped to UniProt O75311. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Glycine receptor subunit alpha-3 is the right protein anchor across sources, using UniProt O75311 as the stable mapping.
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| Preferred Name | Glycine receptor subunit alpha-3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O75311 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glycine receptor subunit alpha-3 |
| UniProt Accession | O75311 |
| Component Type | Protein |
| Sequence Length | 464 aa |
Glycine receptor subunit alpha-3
Review this target as Glycine receptor subunit alpha-3, mapped to UniProt O75311. Sequence length is 464 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4070615 | 7.96 | Kd | 11.0 | Preclinical |
| CHEMBL4070615 | 7.3 | EC50 | 50.0 | Preclinical |
| CHEMBL4083687 | 7.16 | Kd | 70.0 | Preclinical |
| CHEMBL4074873 | 6.72 | Kd | 190.0 | Preclinical |
| CHEMBL4284872 | 6.52 | Kd | 300.0 | Preclinical |
| CHEMBL4074873 | 6.35 | EC50 | 450.0 | Preclinical |
| CHEMBL1314103 | 5.41 | EC50 | 3900.0 | Preclinical |
| CHEMBL464651 | 5.16 | IC50 | 7000.0 | Preclinical |
| CHEMBL4226572 | 5.07 | EC50 | 8500.0 | Preclinical |
| CHEMBL1092618 | 4.52 | IC50 | 30000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 10 | 6 | 6.1 |
| single protein format | 1 | 2 | 6.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 5 | 4.7 |