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Target Snapshot

CHEMBL1075100 Target Snapshot

Sialidase · SINGLE PROTEIN · Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

21Compounds
5Assays
0Approved Drugs
21.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P0C6E9. Use UniProt P0C6E9 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P0C6E9 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Sialidase as ChEMBL target CHEMBL1075100, mapped to UniProt P0C6E9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Sialidase
SINGLE PROTEIN · Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
As of 2026-09-14
ChEMBL target ID
CHEMBL1075100
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P0C6E9
Sialidase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Sialidase is the right protein anchor across sources, using UniProt P0C6E9 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSialidase
UniProt AccessionP0C6E9
Component TypeProtein
Sequence Length781 aa

Sialidase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Sialidase, mapped to UniProt P0C6E9. Sequence length is 781 aa.

Mapped IDP0C6E9
Review nameSialidase
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Assay Mix

Activity Type Distribution

IC5021.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1096406 6.46 IC50 350.0 Preclinical
CHEMBL1097045 5.48 IC50 3300.0 Preclinical
CHEMBL1096407 5.12 IC50 7550.0 Preclinical
CHEMBL96712 5.07 IC50 8600.0 Preclinical
CHEMBL4289476 4.96 IC50 10900.0 Preclinical
CHEMBL1088321 4.94 IC50 11590.0 Preclinical
CHEMBL4282280 4.87 IC50 13500.0 Preclinical
CHEMBL1086764 4.71 IC50 19480.0 Preclinical
CHEMBL1289311 4.7 IC50 20000.0 Preclinical
CHEMBL454849 4.66 IC50 22030.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
0
5.5
1
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

5
Total Assays
20
Tested Compounds
1
Assay Types
Binding — 5 assays, 20 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 5 20 4.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine