Leucine-rich repeat serine/threonine-protein kinase 2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q5S007. Use UniProt Q5S007 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q5S007 as the stable identity anchor, then attach disease evidence before program review.
Leucine-rich repeat serine/threonine-protein kinase 2
Review this target as Leucine-rich repeat serine/threonine-protein kinase 2, mapped to UniProt Q5S007. Sequence length is 2527 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Leucine-rich repeat serine/threonine-protein kinase 2 as ChEMBL target CHEMBL1075104, mapped to UniProt Q5S007. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Leucine-rich repeat serine/threonine-protein kinase 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q5S007 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Leucine-rich repeat serine/threonine-protein kinase 2 |
| UniProt Accession | Q5S007 |
| Component Type | Protein |
| Sequence Length | 2527 aa |
Leucine-rich repeat serine/threonine-protein kinase 2
Review this target as Leucine-rich repeat serine/threonine-protein kinase 2, mapped to UniProt Q5S007. Sequence length is 2527 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3969077 | 10.22 | Ki | 0.06 | Preclinical |
| CHEMBL5189225 | 10.19 | IC50 | 0.06457 | Preclinical |
| CHEMBL5195441 | 10.12 | IC50 | 0.07586 | Preclinical |
| CHEMBL5283143 | 10.09 | IC50 | 0.08128 | Preclinical |
| CHEMBL5273196 | 10.09 | IC50 | 0.08128 | Preclinical |
| CHEMBL5266868 | 10.09 | IC50 | 0.08128 | Preclinical |
| CHEMBL5198416 | 10.09 | IC50 | 0.08128 | Preclinical |
| CHEMBL5177202 | 10.09 | IC50 | 0.08128 | Preclinical |
| CHEMBL5191262 | 10.09 | IC50 | 0.08128 | Preclinical |
| CHEMBL5171075 | 10.09 | IC50 | 0.08128 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 436 | 2,848 | 7.5 |
| cell-based format | 184 | 498 | 7.0 |
| assay format | 123 | 243 | 7.0 |
| subcellular format | 8 | 2 | 8.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 6 | 6 | 7.0 |
| single protein format | 1 | 12 | 7.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| subcellular format | 2 | 1 | 7.3 |
| assay format | 1 | 198 | 6.3 |