Heat shock protein 75 kDa, mitochondrial · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q12931. Use UniProt Q12931 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q12931 as the stable identity anchor, then attach disease evidence before program review.
Heat shock protein 75 kDa, mitochondrial
Review this target as Heat shock protein 75 kDa, mitochondrial, mapped to UniProt Q12931. Sequence length is 704 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Heat shock protein 75 kDa, mitochondrial as ChEMBL target CHEMBL1075132, mapped to UniProt Q12931. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Heat shock protein 75 kDa, mitochondrial |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q12931 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Heat shock protein 75 kDa, mitochondrial |
| UniProt Accession | Q12931 |
| Component Type | Protein |
| Sequence Length | 704 aa |
Heat shock protein 75 kDa, mitochondrial
Review this target as Heat shock protein 75 kDa, mitochondrial, mapped to UniProt Q12931. Sequence length is 704 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1910764 | 8.24 | Kd | 5.8 | Preclinical |
| CHEMBL2419342 | 8.23 | Kd | 5.9 | Preclinical |
| CHEMBL4126250 | 8.0 | Kd | 10.0 | Preclinical |
| CHEMBL252164 | 7.8 | Ki | 16.0 | Clinical |
| CHEMBL2103879 | 7.42 | IC50 | 37.7 | Clinical |
| CHEMBL252164 | 7.42 | IC50 | 38.0 | Clinical |
| CHEMBL5633816 | 7.4 | Kd | 40.0 | Preclinical |
| CHEMBL5633903 | 7.4 | Kd | 40.0 | Preclinical |
| CHEMBL2419341 | 7.29 | Kd | 51.8 | Preclinical |
| CHEMBL4866705 | 7.24 | IC50 | 58.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 29 | 18 | 6.0 |
| single protein format | 21 | 115 | 6.0 |
| cell-based format | 18 | 0 | — |