Elastase · SINGLE PROTEIN · Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228)
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P14756. Use UniProt P14756 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P14756 as the stable identity anchor, then attach disease evidence before program review.
Elastase
Review this target as Elastase, mapped to UniProt P14756. Sequence length is 498 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Elastase as ChEMBL target CHEMBL1075146, mapped to UniProt P14756. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Elastase is the right protein anchor across sources, using UniProt P14756 as the stable mapping.
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| Preferred Name | Elastase |
| Target Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) |
| UniProt | P14756 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Elastase |
| UniProt Accession | P14756 |
| Component Type | Protein |
| Sequence Length | 498 aa |
Elastase
Review this target as Elastase, mapped to UniProt P14756. Sequence length is 498 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4647152 | 7.39 | Ki | 40.5 | Preclinical |
| CHEMBL4754924 | 7.39 | Ki | 41.0 | Preclinical |
| CHEMBL479579 | 7.24 | Ki | 57.0 | Preclinical |
| CHEMBL234737 | 6.4 | IC50 | 400.0 | Preclinical |
| CHEMBL1079252 | 6.11 | Ki | 770.0 | Preclinical |
| CHEMBL5285201 | 6.0 | IC50 | 1000.0 | Preclinical |
| CHEMBL1079155 | 5.96 | Ki | 1100.0 | Preclinical |
| CHEMBL228230 | 5.96 | IC50 | 1100.0 | Preclinical |
| CHEMBL1078278 | 5.89 | Ki | 1300.0 | Preclinical |
| CHEMBL1078192 | 5.75 | Ki | 1800.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 21 | 177 | 4.8 |
| assay format | 2 | 9 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 13 | 5.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-free format | 1 | 0 | — |
| single protein format | 1 | 0 | — |