Cystine/glutamate transporter · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9UPY5. Use UniProt Q9UPY5 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9UPY5 as the stable identity anchor, then attach disease evidence before program review.
Cystine/glutamate transporter
Review this target as Cystine/glutamate transporter, mapped to UniProt Q9UPY5. Sequence length is 501 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cystine/glutamate transporter as ChEMBL target CHEMBL1075149, mapped to UniProt Q9UPY5. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cystine/glutamate transporter |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9UPY5 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cystine/glutamate transporter |
| UniProt Accession | Q9UPY5 |
| Component Type | Protein |
| Sequence Length | 501 aa |
Cystine/glutamate transporter
Review this target as Cystine/glutamate transporter, mapped to UniProt Q9UPY5. Sequence length is 501 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3629669 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL3629579 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL3629668 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL5571379 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL3629578 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL3629576 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL3629671 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL5564194 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL3629577 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL3629575 | 7.22 | IC50 | 60.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 64 | 35 | 6.2 |
| single protein format | 4 | 15 | 5.0 |
| cell-free format | 3 | 0 | — |