Beta-lactamase · SINGLE PROTEIN · Acinetobacter baumannii
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As of 2026-09-13Beta-lactamase shows clinical signal disease relevance led by bacterial disease. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q8RLA6. Start with bacterial disease, then reuse UniProt Q8RLA6 as the stable protein anchor across project notes and exports.
Start with bacterial disease, then reuse UniProt Q8RLA6 as the stable protein anchor across project notes and exports.
Beta-lactamase shows clinical signal disease relevance led by bacterial disease. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with bacterial disease because it currently carries clinical signal support. Linked drugs include DURLOBACTAM SODIUM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyBeta-lactamase
Review this target as Beta-lactamase, mapped to UniProt Q8RLA6. Sequence length is 275 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Beta-lactamase as ChEMBL target CHEMBL1075159, mapped to UniProt Q8RLA6. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Beta-lactamase is the right protein anchor across sources, using UniProt Q8RLA6 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why bacterial disease is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Beta-lactamase |
| Target Type | SINGLE PROTEIN |
| Organism | Acinetobacter baumannii |
| UniProt | Q8RLA6 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Beta-lactamase |
| UniProt Accession | Q8RLA6 |
| Component Type | Protein |
| Sequence Length | 275 aa |
Beta-lactamase
Review this target as Beta-lactamase, mapped to UniProt Q8RLA6. Sequence length is 275 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Beta-lactamase shows clinical signal disease relevance led by bacterial disease. 1 more disease program remain visible in the same review block.
Start review with bacterial disease because it currently carries clinical signal support. Linked drugs include DURLOBACTAM SODIUM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3112591 | 6.44 | IC50 | 360.0 | Preclinical |
| CHEMBL3112748 | 6.28 | IC50 | 530.0 | Preclinical |
| CHEMBL3112749 | 5.36 | IC50 | 4400.0 | Preclinical |
| CHEMBL3112751 | 5.32 | IC50 | 4800.0 | Preclinical |
| CHEMBL1089781 | 5.25 | IC50 | 5600.0 | Preclinical |
| CHEMBL3112755 | 4.89 | IC50 | 13000.0 | Preclinical |
| CHEMBL1795567 | 4.77 | IC50 | 17000.0 | Preclinical |
| CHEMBL3112746 | 4.7 | IC50 | 20000.0 | Preclinical |
| CHEMBL3112747 | 4.7 | IC50 | 20000.0 | Preclinical |
| CHEMBL1795568 | 4.68 | IC50 | 21000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 94 | 14 | 5.0 |