Phosphatidylinositol 3-kinase catalytic subunit type 3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q8NEB9. Use UniProt Q8NEB9 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8NEB9 as the stable identity anchor, then attach disease evidence before program review.
Phosphatidylinositol 3-kinase catalytic subunit type 3
Review this target as Phosphatidylinositol 3-kinase catalytic subunit type 3, mapped to UniProt Q8NEB9. Sequence length is 887 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Phosphatidylinositol 3-kinase catalytic subunit type 3 as ChEMBL target CHEMBL1075165, mapped to UniProt Q8NEB9. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q8NEB9 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
| UniProt Accession | Q8NEB9 |
| Component Type | Protein |
| Sequence Length | 887 aa |
Phosphatidylinositol 3-kinase catalytic subunit type 3
Review this target as Phosphatidylinositol 3-kinase catalytic subunit type 3, mapped to UniProt Q8NEB9. Sequence length is 887 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL273832 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL5286775 | 9.28 | Kd | 0.53 | Preclinical |
| CHEMBL3622372 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5404351 | 9.0 | Kd | 1.0 | Preclinical |
| CHEMBL5982739 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL3622372 | 8.96 | EC50 | 1.11 | Preclinical |
| CHEMBL4561242 | 8.8 | IC50 | 1.585 | Preclinical |
| CHEMBL2140173 | 8.77 | Kd | 1.7 | Preclinical |
| CHEMBL5192406 | 8.77 | IC50 | 1.7 | Preclinical |
| CHEMBL4517404 | 8.7 | IC50 | 2.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 122 | 555 | 7.4 |
| cell-based format | 43 | 34 | 7.1 |
| assay format | 31 | 106 | 6.1 |
| subcellular format | 25 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 3 | 10 | 7.4 |
| tissue-based format | 1 | 1 | 7.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |