Homeodomain-interacting protein kinase 4 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-12Protein identity stays anchored to UniProt Q8NE63. Use UniProt Q8NE63 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8NE63 as the stable identity anchor, then attach disease evidence before program review.
Homeodomain-interacting protein kinase 4
Review this target as Homeodomain-interacting protein kinase 4, mapped to UniProt Q8NE63. Sequence length is 616 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Homeodomain-interacting protein kinase 4 as ChEMBL target CHEMBL1075167, mapped to UniProt Q8NE63. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Homeodomain-interacting protein kinase 4 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q8NE63 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Homeodomain-interacting protein kinase 4 |
| UniProt Accession | Q8NE63 |
| Component Type | Protein |
| Sequence Length | 616 aa |
Homeodomain-interacting protein kinase 4
Review this target as Homeodomain-interacting protein kinase 4, mapped to UniProt Q8NE63. Sequence length is 616 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1230609 | 9.29 | Kd | 0.51 | Clinical |
| CHEMBL1336 | 8.57 | Kd | 2.7 | Approved |
| CHEMBL4855209 | 8.55 | IC50 | 2.8 | Preclinical |
| CHEMBL1336 | 8.52 | IC50 | 3.0 | Approved |
| CHEMBL4859179 | 8.48 | IC50 | 3.3 | Preclinical |
| CHEMBL574738 | 8.41 | Kd | 3.9 | Preclinical |
| CHEMBL2000335 | 8.4 | Ki | 3.981 | Preclinical |
| CHEMBL2004716 | 8.4 | Ki | 3.981 | Preclinical |
| CHEMBL411903 | 8.3 | Ki | 5.012 | Preclinical |
| CHEMBL4850066 | 8.29 | IC50 | 5.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 167 | 63 | 6.6 |
| assay format | 30 | 1 | 6.8 |
| cell-based format | 7 | 4 | 5.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 273 | 6.3 |