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Target Snapshot

CHEMBL1075178 Target Snapshot

Neuromedin-U receptor 1 · SINGLE PROTEIN · Homo sapiens

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244Compounds
48Assays
0Approved Drugs
186.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9HB89. Use UniProt Q9HB89 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9HB89 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Neuromedin-U receptor 1 as ChEMBL target CHEMBL1075178, mapped to UniProt Q9HB89. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Neuromedin-U receptor 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1075178
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9HB89
Neuromedin-U receptor 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Neuromedin-U receptor 1 is the right protein anchor across sources, using UniProt Q9HB89 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNeuromedin-U receptor 1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9HB89
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNeuromedin-U receptor 1
UniProt AccessionQ9HB89
Component TypeProtein
Sequence Length426 aa

Neuromedin-U receptor 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Neuromedin-U receptor 1, mapped to UniProt Q9HB89. Sequence length is 426 aa.

Mapped IDQ9HB89
Review nameNeuromedin-U receptor 1
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC5055.0
KI4.0
EC50125.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4174679 10.43 IC50 0.037 Preclinical
CHEMBL3425593 10.08 EC50 0.083 Preclinical
CHEMBL4165538 10.07 IC50 0.086 Preclinical
CHEMBL4162728 10.04 IC50 0.092 Preclinical
CHEMBL3315349 9.85 EC50 0.14 Preclinical
CHEMBL4177021 9.82 IC50 0.15 Preclinical
CHEMBL4069151 9.77 EC50 0.17 Preclinical
CHEMBL4105671 9.6 EC50 0.25 Preclinical
CHEMBL4169726 9.54 IC50 0.29 Preclinical
CHEMBL4098010 9.51 EC50 0.31 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
8
5.5
11
6.0
15
6.5
33
7.0
19
7.5
21
8.0
15
8.5
24
9.0
8
9.5
pChEMBL
Assay Landscape

Assay Landscape

48
Total Assays
87
Tested Compounds
3
Assay Types
Functional — 32 assays, 87 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 32 87 7.4
Binding — 9 assays, 47 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 7 0 —
cell-based format 2 47 8.1
ADME — 7 assays, 24 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 7 24 8.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine