Use UniProt Q8HY88 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL1075183 Target Snapshot
Potassium channel subfamily K member 2 · SINGLE PROTEIN · Bos taurus
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As of 2026-09-14Protein identity stays anchored to UniProt Q8HY88. Use UniProt Q8HY88 as the stable identity anchor, then attach disease evidence before program review.
Potassium channel subfamily K member 2
Review this target as Potassium channel subfamily K member 2, mapped to UniProt Q8HY88. Sequence length is 411 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Potassium channel subfamily K member 2 as ChEMBL target CHEMBL1075183, mapped to UniProt Q8HY88. Disease framing currently uses the Open Targets-ready proxy contract.
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Open Review-ready CardBasic Information
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| Preferred Name | Potassium channel subfamily K member 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Bos taurus |
| UniProt | Q8HY88 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Potassium channel subfamily K member 2 |
| UniProt Accession | Q8HY88 |
| Component Type | Protein |
| Sequence Length | 411 aa |
Potassium channel subfamily K member 2
How to read this target
Review this target as Potassium channel subfamily K member 2, mapped to UniProt Q8HY88. Sequence length is 411 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1491 | 6.37 | IC50 | 430.0 | Approved |
| CHEMBL1275655 | 6.12 | IC50 | 750.0 | Preclinical |
| CHEMBL140 | 6.03 | IC50 | 930.0 | Clinical |
| CHEMBL15848 | 6.0 | IC50 | 1000.0 | Preclinical |
| CHEMBL30008 | 5.6 | IC50 | 2500.0 | Clinical |
| CHEMBL193 | 5.09 | IC50 | 8200.0 | Approved |
pChEMBL Value Distribution
Approved Drugs
Assay Landscape
Binding — 4 assays, 6 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 6 | 5.9 |