Target Snapshot

CHEMBL1075189 Target Snapshot

Pyruvate kinase PKM · SINGLE PROTEIN · Homo sapiens

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7,233Compounds

344Assays

5Approved Drugs

349.0Activities

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P14618. Use UniProt P14618 as the stable identity anchor, then attach disease evidence before program review.

Review focus

Protein anchor ready

Use UniProt P14618 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13

Open source guide

Protein anchor

Pyruvate kinase PKM

Review this target as Pyruvate kinase PKM, mapped to UniProt P14618. Sequence length is 531 aa.

Protein source · UniProt accession via ChEMBL component mapping

UniProt P14618 Protein 531 aa

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Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Pyruvate kinase PKM as ChEMBL target CHEMBL1075189, mapped to UniProt P14618. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor

Pyruvate kinase PKM

SINGLE PROTEIN · Homo sapiens

As of 2026-09-13

ChEMBL target ID

CHEMBL1075189

Primary anchor for compounds, assays, approvals, and exports

ChEMBL 36 via Core Engine As of 2026-09-13

www.ebi.ac.uk

UniProt accession

P14618

Pyruvate kinase PKM

UniProt accession via ChEMBL component mapping As of 2026-09-13

www.uniprot.org

Disease evidence contract

Open Targets-ready proxy

ChEMBL drug mechanism + indication proxy

ChEMBL drug mechanism + indication proxy As of 2026-09-13

www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context

UniProt accession via ChEMBL component mapping

Start here when your first question is whether Pyruvate kinase PKM is the right protein anchor across sources, using UniProt P14618 as the stable mapping.

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Disease Relevance & Evidence Level

ChEMBL drug mechanism + indication proxy

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Evidence Card

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Overview

Basic Information

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Preferred Name	Pyruvate kinase PKM
Target Type	SINGLE PROTEIN
Organism	Homo sapiens
UniProt	P14618

ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Label	Pyruvate kinase PKM
UniProt Accession	P14618
Component Type	Protein
Sequence Length	531 aa

Pyruvate kinase PKM

Source · UniProt accession via ChEMBL component mapping Freshness · Sep 14, 2026, 5:45 AM KST As of · Sep 13, 2026

UniProt Context ↗

Review Cue

How to read this target

Review this target as Pyruvate kinase PKM, mapped to UniProt P14618. Sequence length is 531 aa.

Mapped IDP14618

Review namePyruvate kinase PKM

OrganismHomo sapiens

Clinical Profile

Clinical Phase Distribution

Approved

Phase III

Phase II

Assay Mix

Activity Type Distribution

IC50220.0

KI8.0

EC50114.0

KD7.0

Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL ID	pChEMBL	Type	Value (nM)	Phase
CHEMBL301523	10.26	IC50	0.055	Clinical
CHEMBL164	9.29	EC50	0.51	Preclinical
CHEMBL5590652	9.22	EC50	0.6	Preclinical
CHEMBL5569778	9.04	Kd	0.915	Preclinical
CHEMBL250450	8.87	EC50	1.34	Clinical
CHEMBL5573729	8.77	IC50	1.7	Preclinical
CHEMBL5563349	8.35	IC50	4.5	Preclinical
CHEMBL449579	8.22	EC50	6.0	Preclinical
CHEMBL5274026	8.15	EC50	7.126	Preclinical
CHEMBL5570128	8.06	IC50	8.8	Preclinical

Distribution

pChEMBL Value Distribution

5.0

5.5

6.0

6.5

7.0

7.5

8.0

8.5

9.0

9.5

pChEMBL

Approved Drugs

MITAPIVAT

CHEMBL4299940

Approved 2022

Properties Compare Identifier

SIROLIMUS

CHEMBL413

Approved 1999

Properties Compare Identifier

Assay Landscape

348

Total Assays

229

Tested Compounds

Assay Types

Binding — 326 assays, 229 compounds

BAO Format	Assays	Compounds	Avg pChEMBL
single protein format	165	168	6.0
cell-based format	122	6	6.5
assay format	37	55	6.2
subcellular format	2	0	—

Functional — 20 assays, 0 compounds

BAO Format	Assays	Compounds	Avg pChEMBL
assay format	20	0	—

ADME — 2 assays, 3 compounds

BAO Format	Assays	Compounds	Avg pChEMBL
assay format	2	3	5.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine Freshness · Sep 14, 2026, 5:45 AM KST As of · Sep 13, 2026