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Target Snapshot

CHEMBL1075226 Target Snapshot

Potassium voltage-gated channel subfamily B member 1 · SINGLE PROTEIN · Rattus norvegicus

8Compounds
2Assays
0Approved Drugs
8.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P15387. Use UniProt P15387 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P15387 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Potassium voltage-gated channel subfamily B member 1 as ChEMBL target CHEMBL1075226, mapped to UniProt P15387. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Potassium voltage-gated channel subfamily B member 1
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL1075226
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P15387
Potassium voltage-gated channel subfamily B member 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Potassium voltage-gated channel subfamily B member 1 is the right protein anchor across sources, using UniProt P15387 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPotassium voltage-gated channel subfamily B member 1
UniProt AccessionP15387
Component TypeProtein
Sequence Length857 aa

Potassium voltage-gated channel subfamily B member 1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Potassium voltage-gated channel subfamily B member 1, mapped to UniProt P15387. Sequence length is 857 aa.

Mapped IDP15387
Review namePotassium voltage-gated channel subfamily B member 1
OrganismRattus norvegicus
Assay Mix

Activity Type Distribution

IC508.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL387935 5.62 IC50 2400.0 Preclinical
CHEMBL229125 5.55 IC50 2800.0 Preclinical
CHEMBL387671 5.5 IC50 3200.0 Preclinical
CHEMBL375475 5.1 IC50 8000.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
3
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
4
Tested Compounds
1
Assay Types
Binding — 2 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0
single protein format 1 4 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine