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Target Snapshot

CHEMBL1075246 Target Snapshot

Xanthine dehydrogenase/oxidase · SINGLE PROTEIN · Rattus norvegicus

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47Compounds
6Assays
2Approved Drugs
41.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P22985. Use UniProt P22985 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P22985 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Xanthine dehydrogenase/oxidase as ChEMBL target CHEMBL1075246, mapped to UniProt P22985. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Xanthine dehydrogenase/oxidase
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL1075246
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P22985
Xanthine dehydrogenase/oxidase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Xanthine dehydrogenase/oxidase is the right protein anchor across sources, using UniProt P22985 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameXanthine dehydrogenase/oxidase
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtP22985
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelXanthine dehydrogenase/oxidase
UniProt AccessionP22985
Component TypeProtein
Sequence Length1331 aa

Xanthine dehydrogenase/oxidase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Xanthine dehydrogenase/oxidase, mapped to UniProt P22985. Sequence length is 1331 aa.

Mapped IDP22985
Review nameXanthine dehydrogenase/oxidase
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC5041.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1164729 8.4 IC50 3.981 Approved
CHEMBL3127117 8.1 IC50 7.943 Preclinical
CHEMBL1644702 6.54 IC50 289.0 Preclinical
CHEMBL1644704 6.44 IC50 362.0 Preclinical
CHEMBL1644703 6.38 IC50 413.0 Preclinical
CHEMBL1641632 6.35 IC50 449.0 Preclinical
CHEMBL1644719 6.26 IC50 555.0 Preclinical
CHEMBL1644713 6.23 IC50 590.0 Preclinical
CHEMBL1644706 6.21 IC50 623.0 Preclinical
CHEMBL1467 6.12 IC50 753.0 Approved
Distribution

pChEMBL Value Distribution

5
5.0
7
5.5
7
6.0
1
6.5
0
7.0
0
7.5
2
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

FEBUXOSTAT
CHEMBL1164729
Approved 2008
Properties Compare Identifier
ALLOPURINOL
CHEMBL1467
Approved 1966
Properties Compare Identifier
Assay Landscape

Assay Landscape

6
Total Assays
31
Tested Compounds
1
Assay Types
Binding — 6 assays, 31 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 5 29 5.3
single protein format 1 2 8.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine