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Target Snapshot

CHEMBL1075263 Target Snapshot

C-C chemokine receptor type 5 · SINGLE PROTEIN · Macaca fascicularis

18Compounds
2Assays
0Approved Drugs
19.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P61814. Use UniProt P61814 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P61814 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats C-C chemokine receptor type 5 as ChEMBL target CHEMBL1075263, mapped to UniProt P61814. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
C-C chemokine receptor type 5
SINGLE PROTEIN · Macaca fascicularis
As of 2026-09-14
ChEMBL target ID
CHEMBL1075263
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P61814
C-C chemokine receptor type 5
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether C-C chemokine receptor type 5 is the right protein anchor across sources, using UniProt P61814 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelC-C chemokine receptor type 5
UniProt AccessionP61814
Component TypeProtein
Sequence Length352 aa

C-C chemokine receptor type 5

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as C-C chemokine receptor type 5, mapped to UniProt P61814. Sequence length is 352 aa.

Mapped IDP61814
Review nameC-C chemokine receptor type 5
OrganismMacaca fascicularis
Assay Mix

Activity Type Distribution

IC5019.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL62152 9.15 IC50 0.7 Preclinical
CHEMBL255856 9.1 IC50 0.8 Preclinical
CHEMBL255429 8.96 IC50 1.1 Preclinical
CHEMBL58387 8.96 IC50 1.1 Preclinical
CHEMBL61424 8.66 IC50 2.2 Preclinical
CHEMBL59511 8.55 IC50 2.8 Preclinical
CHEMBL301454 8.52 IC50 3.0 Preclinical
CHEMBL255644 8.49 IC50 3.2 Preclinical
CHEMBL556314 8.47 IC50 3.4 Preclinical
CHEMBL401929 8.44 IC50 3.6 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
1
6.5
2
7.0
2
7.5
7
8.0
5
8.5
2
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
18
Tested Compounds
2
Assay Types
Binding — 1 assays, 18 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 18 8.3
Functional — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 1 7.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine