Dual specificity protein kinase CLK2 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt O35491. Use UniProt O35491 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O35491 as the stable identity anchor, then attach disease evidence before program review.
Dual specificity protein kinase CLK2
Review this target as Dual specificity protein kinase CLK2, mapped to UniProt O35491. Sequence length is 499 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dual specificity protein kinase CLK2 as ChEMBL target CHEMBL1075281, mapped to UniProt O35491. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Dual specificity protein kinase CLK2 is the right protein anchor across sources, using UniProt O35491 as the stable mapping.
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| Preferred Name | Dual specificity protein kinase CLK2 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | O35491 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dual specificity protein kinase CLK2 |
| UniProt Accession | O35491 |
| Component Type | Protein |
| Sequence Length | 499 aa |
Dual specificity protein kinase CLK2
Review this target as Dual specificity protein kinase CLK2, mapped to UniProt O35491. Sequence length is 499 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4082113 | 7.72 | IC50 | 19.1 | Preclinical |
| CHEMBL4061526 | 7.55 | IC50 | 28.0 | Preclinical |
| CHEMBL4102871 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL5200518 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL4071322 | 7.5 | IC50 | 32.0 | Preclinical |
| CHEMBL5179655 | 7.46 | IC50 | 35.0 | Preclinical |
| CHEMBL4070189 | 7.33 | IC50 | 47.0 | Preclinical |
| CHEMBL4065432 | 7.28 | IC50 | 52.0 | Preclinical |
| CHEMBL3589661 | 7.26 | IC50 | 55.0 | Preclinical |
| CHEMBL4072506 | 7.23 | IC50 | 59.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 10 | 119 | 6.2 |
| single protein format | 3 | 2 | 7.2 |