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Target Snapshot

CHEMBL1075291 Target Snapshot

Probable G-protein coupled receptor 34 · SINGLE PROTEIN · Mus musculus

108Compounds
16Assays
0Approved Drugs
215.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9R1K6. Use UniProt Q9R1K6 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9R1K6 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Probable G-protein coupled receptor 34 as ChEMBL target CHEMBL1075291, mapped to UniProt Q9R1K6. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Probable G-protein coupled receptor 34
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL1075291
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9R1K6
Probable G-protein coupled receptor 34
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Probable G-protein coupled receptor 34 is the right protein anchor across sources, using UniProt Q9R1K6 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProbable G-protein coupled receptor 34
UniProt AccessionQ9R1K6
Component TypeProtein
Sequence Length375 aa

Probable G-protein coupled receptor 34

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Probable G-protein coupled receptor 34, mapped to UniProt Q9R1K6. Sequence length is 375 aa.

Mapped IDQ9R1K6
Review nameProbable G-protein coupled receptor 34
OrganismMus musculus
Assay Mix

Activity Type Distribution

EC50215.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4753103 9.08 EC50 0.83 Preclinical
CHEMBL4759297 8.54 EC50 2.884 Preclinical
CHEMBL4782438 8.46 EC50 3.5 Preclinical
CHEMBL4758243 8.3 EC50 5.0 Preclinical
CHEMBL4759762 8.25 EC50 5.623 Preclinical
CHEMBL4776455 8.21 EC50 6.1 Preclinical
CHEMBL4745697 8.2 EC50 6.3 Preclinical
CHEMBL4062945 8.1 EC50 7.9 Preclinical
CHEMBL4759998 8.05 EC50 9.0 Preclinical
CHEMBL4764776 7.97 EC50 10.72 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
16
5.5
38
6.0
53
6.5
21
7.0
10
7.5
14
8.0
2
8.5
2
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

16
Total Assays
70
Tested Compounds
2
Assay Types
Binding — 10 assays, 70 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 10 70 6.9
Functional — 6 assays, 5 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 6 5 6.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine