Hemagglutinin · SINGLE PROTEIN · Influenza A virus (A/Puerto Rico/8/1934(H1N1))
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As of 2026-09-14Hemagglutinin shows clinical signal disease relevance led by influenza. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P03452. Start with influenza, then reuse UniProt P03452 as the stable protein anchor across project notes and exports.
Start with influenza, then reuse UniProt P03452 as the stable protein anchor across project notes and exports.
Hemagglutinin shows clinical signal disease relevance led by influenza. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with influenza because it currently carries clinical signal support. Linked drugs include DIRIDAVUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyHemagglutinin
Review this target as Hemagglutinin, mapped to UniProt P03452. Sequence length is 565 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Hemagglutinin as ChEMBL target CHEMBL1075313, mapped to UniProt P03452. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Hemagglutinin is the right protein anchor across sources, using UniProt P03452 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why influenza is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Hemagglutinin |
| Target Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
| UniProt | P03452 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Hemagglutinin |
| UniProt Accession | P03452 |
| Component Type | Protein |
| Sequence Length | 565 aa |
Hemagglutinin
Review this target as Hemagglutinin, mapped to UniProt P03452. Sequence length is 565 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Hemagglutinin shows clinical signal disease relevance led by influenza. 1 more disease program remain visible in the same review block.
Start review with influenza because it currently carries clinical signal support. Linked drugs include DIRIDAVUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1084188 | 8.11 | Kd | 7.8 | Preclinical |
| CHEMBL1084191 | 8.11 | Kd | 7.8 | Preclinical |
| CHEMBL1084190 | 7.96 | Kd | 11.0 | Preclinical |
| CHEMBL1084192 | 7.72 | Kd | 19.0 | Preclinical |
| CHEMBL1084189 | 7.52 | Kd | 30.0 | Preclinical |
| CHEMBL4855404 | 5.58 | Kd | 2630.0 | Preclinical |
| CHEMBL4645411 | 5.35 | Kd | 4500.0 | Preclinical |
| CHEMBL4639026 | 5.2 | Kd | 6300.0 | Preclinical |
| CHEMBL5632136 | 5.19 | Kd | 6400.0 | Preclinical |
| CHEMBL1934618 | 5.11 | IC50 | 7810.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 13 | 3 | 5.0 |
| assay format | 9 | 0 | — |
| single protein format | 8 | 13 | 5.9 |