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Target Snapshot

CHEMBL1075315 Target Snapshot

C-X-C chemokine receptor type 5 · SINGLE PROTEIN · Homo sapiens

169Compounds
33Assays
0Approved Drugs
110.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P32302. Use UniProt P32302 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P32302 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats C-X-C chemokine receptor type 5 as ChEMBL target CHEMBL1075315, mapped to UniProt P32302. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
C-X-C chemokine receptor type 5
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1075315
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P32302
C-X-C chemokine receptor type 5
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether C-X-C chemokine receptor type 5 is the right protein anchor across sources, using UniProt P32302 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelC-X-C chemokine receptor type 5
UniProt AccessionP32302
Component TypeProtein
Sequence Length372 aa

C-X-C chemokine receptor type 5

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as C-X-C chemokine receptor type 5, mapped to UniProt P32302. Sequence length is 372 aa.

Mapped IDP32302
Review nameC-X-C chemokine receptor type 5
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC50107.0
EC503.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3719134 8.3 IC50 5.0 Preclinical
CHEMBL3715759 8.15 IC50 7.0 Preclinical
CHEMBL3717162 8.05 IC50 9.0 Preclinical
CHEMBL3718924 7.96 IC50 11.0 Preclinical
CHEMBL3718468 7.89 IC50 13.0 Preclinical
CHEMBL3717006 7.85 IC50 14.0 Preclinical
CHEMBL3716436 7.82 IC50 15.0 Preclinical
CHEMBL3717871 7.82 IC50 15.0 Preclinical
CHEMBL3719066 7.77 IC50 17.0 Preclinical
CHEMBL3719322 7.64 IC50 23.0 Preclinical
Distribution

pChEMBL Value Distribution

11
5.0
5
5.5
7
6.0
6
6.5
7
7.0
9
7.5
3
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

33
Total Assays
76
Tested Compounds
2
Assay Types
Binding — 21 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 21 1 6.6
Functional — 12 assays, 76 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 6 18 4.8
cell-based format 5 58 6.2
single protein format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine