Glycogen synthase kinase-3 beta · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt Q9WV60. Use UniProt Q9WV60 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9WV60 as the stable identity anchor, then attach disease evidence before program review.
Glycogen synthase kinase-3 beta
Review this target as Glycogen synthase kinase-3 beta, mapped to UniProt Q9WV60. Sequence length is 420 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Glycogen synthase kinase-3 beta as ChEMBL target CHEMBL1075321, mapped to UniProt Q9WV60. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Glycogen synthase kinase-3 beta |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | Q9WV60 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glycogen synthase kinase-3 beta |
| UniProt Accession | Q9WV60 |
| Component Type | Protein |
| Sequence Length | 420 aa |
Glycogen synthase kinase-3 beta
Review this target as Glycogen synthase kinase-3 beta, mapped to UniProt Q9WV60. Sequence length is 420 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2177155 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL1682552 | 8.0 | Ki | 10.0 | Preclinical |
| CHEMBL2177165 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL2182002 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL405759 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL2177166 | 7.43 | IC50 | 37.0 | Preclinical |
| CHEMBL2177167 | 7.33 | IC50 | 47.0 | Preclinical |
| CHEMBL2177157 | 7.31 | IC50 | 49.0 | Preclinical |
| CHEMBL2177161 | 7.12 | IC50 | 76.0 | Preclinical |
| CHEMBL2177159 | 7.1 | IC50 | 79.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 38 | 12 | 7.2 |
| assay format | 1 | 0 | — |
| tissue-based format | 1 | 0 | — |