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Target Snapshot

CHEMBL1075322 Target Snapshot

G-protein coupled receptor 55 · SINGLE PROTEIN · Homo sapiens

1,043Compounds
91Assays
7Approved Drugs
1,128.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9Y2T6. Use UniProt Q9Y2T6 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9Y2T6 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats G-protein coupled receptor 55 as ChEMBL target CHEMBL1075322, mapped to UniProt Q9Y2T6. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
G-protein coupled receptor 55
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1075322
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9Y2T6
G-protein coupled receptor 55
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether G-protein coupled receptor 55 is the right protein anchor across sources, using UniProt Q9Y2T6 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelG-protein coupled receptor 55
UniProt AccessionQ9Y2T6
Component TypeProtein
Sequence Length319 aa

G-protein coupled receptor 55

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as G-protein coupled receptor 55, mapped to UniProt Q9Y2T6. Sequence length is 319 aa.

Mapped IDQ9Y2T6
Review nameG-protein coupled receptor 55
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

7
Approved
2
Phase II
Assay Mix

Activity Type Distribution

IC50667.0
EC50458.0
KD3.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5414688 9.64 EC50 0.227 Preclinical
CHEMBL5428306 9.62 EC50 0.239 Preclinical
CHEMBL3781437 9.4 EC50 0.4 Preclinical
CHEMBL5426486 9.36 EC50 0.439 Preclinical
CHEMBL3781953 9.29 EC50 0.51 Preclinical
CHEMBL3779969 9.22 EC50 0.6 Preclinical
CHEMBL3781521 9.16 EC50 0.69 Preclinical
CHEMBL3781158 9.06 EC50 0.88 Preclinical
CHEMBL3779954 8.89 EC50 1.28 Preclinical
CHEMBL3402654 8.7 EC50 2.0 Preclinical
Distribution

pChEMBL Value Distribution

223
5.0
215
5.5
128
6.0
24
6.5
9
7.0
19
7.5
8
8.0
7
8.5
6
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

CANNABIDIOL
CHEMBL190461
Approved 2018
BISACODYL
CHEMBL942
Approved 2004
Assay Landscape

Assay Landscape

91
Total Assays
575
Tested Compounds
2
Assay Types
Binding — 55 assays, 96 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 48 90 6.1
single protein format 6 4 6.2
assay format 1 2 6.7
Functional — 36 assays, 575 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 27 78 6.5
assay format 9 497 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine