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Target Snapshot

CHEMBL1075385 Target Snapshot

769-P · CELL-LINE · Homo sapiens

488Compounds
31Assays
26Approved Drugs
465.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 769-P as ChEMBL target CHEMBL1075385. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
769-P
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1075385
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether 769-P still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Label769-P
UniProt AccessionN/A

769-P

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as 769-P.

Review name769-P
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

26
Approved
10
Phase III
9
Phase II
6
Phase I
Assay Mix

Activity Type Distribution

IC50465.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL888 9.91 IC50 0.1231 Approved
CHEMBL94657 9.12 IC50 0.7534 Clinical
CHEMBL2107358 8.17 IC50 6.778 Clinical
CHEMBL105 8.15 IC50 7.112 Approved
CHEMBL1972860 8.01 IC50 9.821 Clinical
CHEMBL1879463 7.98 IC50 10.44 Clinical
CHEMBL252164 7.97 IC50 10.73 Clinical
CHEMBL553025 7.77 IC50 16.92 Approved
CHEMBL3688339 7.7 IC50 20.1 Preclinical
CHEMBL3672295 7.68 IC50 20.7 Preclinical
Distribution

pChEMBL Value Distribution

69
5.0
33
5.5
21
6.0
6
6.5
3
7.0
8
7.5
3
8.0
0
8.5
1
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
CYTARABINE
CHEMBL803
Approved 1969
VINBLASTINE
CHEMBL159
Approved 1965
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

31
Total Assays
360
Tested Compounds
2
Assay Types
Functional — 30 assays, 360 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 30 360 5.2
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine