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Target Snapshot

CHEMBL1075401 Target Snapshot

C32 · CELL-LINE · Homo sapiens

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241Compounds
31Assays
21Approved Drugs
208.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats C32 as ChEMBL target CHEMBL1075401. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
C32
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1075401
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether C32 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameC32
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelC32
UniProt AccessionN/A

C32

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as C32.

Review nameC32
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

21
Approved
9
Phase III
9
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50208.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL109480 8.52 IC50 3.045 Clinical
CHEMBL507361 8.44 IC50 3.668 Clinical
CHEMBL2363137 8.17 IC50 6.742 Preclinical
CHEMBL1614766 8.08 IC50 8.4 Preclinical
CHEMBL5440394 7.92 IC50 12.0 Preclinical
CHEMBL65 7.87 IC50 13.37 Preclinical
CHEMBL98745 7.6 IC50 25.0 Preclinical
CHEMBL1972860 7.58 IC50 26.3 Clinical
CHEMBL1201182 7.33 IC50 46.64 Approved
CHEMBL3264002 7.33 IC50 47.0 Clinical
Distribution

pChEMBL Value Distribution

21
5.0
20
5.5
11
6.0
12
6.5
8
7.0
4
7.5
3
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

SELUMETINIB
CHEMBL1614701
Approved 2020
Properties Compare Identifier
VEMURAFENIB
CHEMBL1229517
Approved 2011
Properties Compare Identifier
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

31
Total Assays
156
Tested Compounds
2
Assay Types
Functional — 27 assays, 156 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 26 156 5.6
organism-based format 1 0 —
ADME — 4 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 4 2 4.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine