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Target Snapshot

CHEMBL1075421 Target Snapshot

ChaGo-K-1 · CELL-LINE · Homo sapiens

116Compounds
7Assays
24Approved Drugs
103.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats ChaGo-K-1 as ChEMBL target CHEMBL1075421. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
ChaGo-K-1
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1075421
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether ChaGo-K-1 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelChaGo-K-1
UniProt AccessionN/A

ChaGo-K-1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as ChaGo-K-1.

Review nameChaGo-K-1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

24
Approved
11
Phase III
11
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50103.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL159 8.99 IC50 1.013 Approved
CHEMBL96926 8.48 IC50 3.289 Preclinical
CHEMBL1972860 8.27 IC50 5.4 Clinical
CHEMBL553025 8.18 IC50 6.686 Approved
CHEMBL94657 8.02 IC50 9.612 Clinical
CHEMBL3545252 8.01 IC50 9.883 Approved
CHEMBL53463 6.97 IC50 107.95 Approved
CHEMBL252164 6.9 IC50 126.99 Clinical
CHEMBL449158 6.55 IC50 280.71 Clinical
CHEMBL217354 6.53 IC50 295.67 Preclinical
Distribution

pChEMBL Value Distribution

15
5.0
8
5.5
7
6.0
6
6.5
0
7.0
0
7.5
5
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TEMSIROLIMUS
CHEMBL1201182
Approved 2007
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
DOXORUBICIN
CHEMBL53463
Approved 1974
VINBLASTINE
CHEMBL159
Approved 1965
Assay Landscape

Assay Landscape

7
Total Assays
101
Tested Compounds
1
Assay Types
Functional — 7 assays, 101 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 7 101 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine