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Target Snapshot

CHEMBL1075451 Target Snapshot

H-EMC-SS · CELL-LINE · Homo sapiens

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75Compounds
5Assays
14Approved Drugs
89.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats H-EMC-SS as ChEMBL target CHEMBL1075451. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
H-EMC-SS
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1075451
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether H-EMC-SS still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameH-EMC-SS
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelH-EMC-SS
UniProt AccessionN/A

H-EMC-SS

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as H-EMC-SS.

Review nameH-EMC-SS
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

14
Approved
7
Phase III
7
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC5089.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1972860 8.43 IC50 3.684 Clinical
CHEMBL507361 7.96 IC50 11.02 Clinical
CHEMBL65 7.02 IC50 95.58 Preclinical
CHEMBL1289926 6.96 IC50 110.05 Approved
CHEMBL260046 6.89 IC50 130.0 Clinical
CHEMBL803 6.84 IC50 145.28 Approved
CHEMBL1879463 6.83 IC50 146.81 Clinical
CHEMBL159 6.59 IC50 255.94 Approved
CHEMBL2041933 6.55 IC50 283.54 Preclinical
CHEMBL1614701 6.54 IC50 290.99 Approved
Distribution

pChEMBL Value Distribution

13
5.0
13
5.5
11
6.0
7
6.5
1
7.0
1
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

SELUMETINIB
CHEMBL1614701
Approved 2020
Properties Compare Identifier
AXITINIB
CHEMBL1289926
Approved 2012
Properties Compare Identifier
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
CYTARABINE
CHEMBL803
Approved 1969
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

5
Total Assays
75
Tested Compounds
2
Assay Types
Functional — 4 assays, 75 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 4 75 5.7
ADME — 1 assays, 14 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 14 4.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine