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Target Snapshot

CHEMBL1075454 Target Snapshot

HCC1395 · CELL-LINE · Homo sapiens

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123Compounds
20Assays
22Approved Drugs
108.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HCC1395 as ChEMBL target CHEMBL1075454. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HCC1395
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1075454
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HCC1395 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHCC1395
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHCC1395
UniProt AccessionN/A

HCC1395

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as HCC1395.

Review nameHCC1395
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

22
Approved
10
Phase III
10
Phase II
6
Phase I
Assay Mix

Activity Type Distribution

IC50106.0
EC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3137320 9.34 IC50 0.46 Approved
CHEMBL3128043 8.8 IC50 1.6 Preclinical
CHEMBL96926 8.5 IC50 3.15 Preclinical
CHEMBL1972860 8.07 IC50 8.469 Clinical
CHEMBL3545252 7.98 IC50 10.56 Approved
CHEMBL553025 7.8 IC50 15.87 Approved
CHEMBL159 7.53 IC50 29.25 Approved
CHEMBL4112930 7.37 EC50 42.5 Clinical
CHEMBL1738758 7.31 IC50 49.0 Clinical
CHEMBL608533 7.07 IC50 84.28 Approved
Distribution

pChEMBL Value Distribution

11
5.0
12
5.5
6
6.0
2
6.5
3
7.0
3
7.5
1
8.0
2
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TALAZOPARIB
CHEMBL3137320
Approved 2018
Properties Compare Identifier
MIDOSTAURIN
CHEMBL608533
Approved 2017
Properties Compare Identifier
PONATINIB
CHEMBL1171837
Approved 2012
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

20
Total Assays
103
Tested Compounds
1
Assay Types
Functional — 20 assays, 103 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 20 103 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine