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Target Snapshot

CHEMBL1075466 Target Snapshot

HO-1-N-1 · CELL-LINE · Homo sapiens

96Compounds
1Assays
24Approved Drugs
97.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HO-1-N-1 as ChEMBL target CHEMBL1075466. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HO-1-N-1
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1075466
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HO-1-N-1 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHO-1-N-1
UniProt AccessionN/A

HO-1-N-1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as HO-1-N-1.

Review nameHO-1-N-1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

24
Approved
9
Phase III
10
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC5097.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3545252 9.55 IC50 0.2813 Approved
CHEMBL65 9.08 IC50 0.8385 Preclinical
CHEMBL94657 8.78 IC50 1.656 Clinical
CHEMBL159 8.76 IC50 1.756 Approved
CHEMBL553025 8.18 IC50 6.652 Approved
CHEMBL1201182 8.09 IC50 8.201 Approved
CHEMBL888 7.62 IC50 23.77 Approved
CHEMBL1972860 7.61 IC50 24.5 Clinical
CHEMBL1879463 7.6 IC50 25.15 Clinical
CHEMBL252164 7.59 IC50 25.49 Clinical
Distribution

pChEMBL Value Distribution

6
5.0
11
5.5
12
6.0
3
6.5
3
7.0
4
7.5
2
8.0
2
8.5
1
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

SELUMETINIB
CHEMBL1614701
Approved 2020
PALBOCICLIB
CHEMBL189963
Approved 2015
AFATINIB
CHEMBL1173655
Approved 2013
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
GEFITINIB
CHEMBL939
Approved 2003
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
CYTARABINE
CHEMBL803
Approved 1969
VINBLASTINE
CHEMBL159
Approved 1965
Assay Landscape

Assay Landscape

1
Total Assays
96
Tested Compounds
1
Assay Types
Functional — 1 assays, 96 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 96 5.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine