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Target Snapshot

CHEMBL1075475 Target Snapshot

HuO-3N1 · CELL-LINE · Homo sapiens

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96Compounds
1Assays
25Approved Drugs
97.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HuO-3N1 as ChEMBL target CHEMBL1075475. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HuO-3N1
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1075475
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HuO-3N1 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHuO-3N1
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHuO-3N1
UniProt AccessionN/A

HuO-3N1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as HuO-3N1.

Review nameHuO-3N1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

25
Approved
11
Phase III
12
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC5097.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3545252 9.52 IC50 0.3025 Approved
CHEMBL159 8.32 IC50 4.827 Approved
CHEMBL65 7.9 IC50 12.65 Preclinical
CHEMBL553025 7.89 IC50 12.98 Approved
CHEMBL1201182 7.64 IC50 23.02 Approved
CHEMBL1972860 7.62 IC50 23.96 Clinical
CHEMBL96926 7.36 IC50 43.25 Preclinical
CHEMBL109480 7.28 IC50 52.37 Clinical
CHEMBL939 7.25 IC50 56.09 Approved
CHEMBL1879463 7.17 IC50 67.31 Clinical
Distribution

pChEMBL Value Distribution

14
5.0
12
5.5
11
6.0
1
6.5
5
7.0
4
7.5
1
8.0
0
8.5
0
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
Properties Compare Identifier
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
GEFITINIB
CHEMBL939
Approved 2003
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
TRETINOIN
CHEMBL38
Approved 1971
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
METHOTREXATE
CHEMBL34259
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

1
Total Assays
96
Tested Compounds
1
Assay Types
Functional — 1 assays, 96 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 96 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine